“The Role of Nutraceutical Supplements in the Treatment of Dyslipidemia”; Mark Houston, MD; The Journal of Clinical Hypertension; Volume 14; No. 2; February 2012.
Dr. Houston’s premise for the development of vascular disease is summed up as follows:
“Dyslipidemia is considered one of the top 5 risk factors for cardiovascular disease (CVD), along with hypertension, diabetes mellitus, smoking, and obesity. The mechanisms by which certain lipids induce vascular damage are complex, but from a pathophysiologic and functional medicine viewpoint, these include inflammation, oxidative stress, and autoimmune dysfunction. These pathophysiologic mechanisms lead to endothelial dysfunction and vascular smooth muscle dysfunction. The vascular consequences are CVD, coronary heart disease (CHD), myocardial infarction (MI), and cerebrovascular accidents (CVA).”
I discussed this in more detail in my last blog post, but in a nutshell, if your body is inflamed and toxic your metabolism and physiology are not going to be functioning optimally and you are going to develop vascular disease. The vascular problems you develop put you at risk for heart attack, stroke, peripheral vascular disease, etc……….
Dr. Houston also is not coming from the old and now outdated concept that eating fat and eggs are bad for you:
Eating Real Food is Not Bad for You! Eating Processed Food is Bad for You!
“Recent studies suggest, however, that dietary cholesterol intake does not significantly alter serum cholesterol levels or CHD and that saturated fats have a minimal influence on serum lipids and CHD risk, whereas monounsaturated and polyunsaturated fats have a favorable influence on serum lipids and CHD risk. Increased refined carbohydrate intake may be more important in changing serum lipids and lipid subfractions than saturated fats and cholesterol through the effects on insulin resistance, atherogenic LDL, LDL particle number, very low density lipoprotein (VLDL), triglycerides, and total HDL and HDL subfractions of cholesterol and thus contribute more to CHD risk than saturated fats.”
“The validity of the Diet Heart Hypothesis, which implies that dietary saturated fats, dietary cholesterol and eggs increase the risk of CHD, has been questioned. Trans fatty acids have definite adverse lipid effects and increase CVD and CHD risk, but omega-3 fatty acids and monounsaturated fats improve serum lipids and reduce CVD risk.”
Native Large LDL vs. Modified LDL
“Native LDL, especially large-type A LDL, is not usually atherogenic until modified. “
Modified forms of LDL: oxidized LDL, glycated LDL, glycol-oxidized LDL and acetylated LDL.
“….reducing the uptake of modified LDL into macrophages by the SRs CD 36 and the inflammatory, oxidative stress, and autoimmune responses, will reduce vascular damage beyond just treating LDL cholesterol level.”
“Reductions in high-sensitivity C-reactive protein (hsCRP), an inflammatory marker, reduce vascular events independent of reductions in LDL cholesterol through numerous mechanisms.”
Cholesterol Lowering Medication Side Effects
Typical lipid lowering medications, such as statins, fibrates, bile acid resin binders, or ezetimibe have numerous side effects:
Statin or fibrate muscle disease
Abnormal liver function tests
Mental status changes
Glucose intolerance or Diabetes Mellitus
Statins also can be the cause of chronic fatigue, exercise-induced fatigue, loss of mean muscle-mass, reductions in Coenzyme Q10, carnitine, vitamin E, vitamin D, selenium, omega 3 fatty acids and free T3 levels (active thyroid hormone).
The rest of this paper by Dr. Houston reviews the nutraceutical supplements in the treatment of dyslipidemia and I will summarize this information in my next few blogs.