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6 Adverse Effects of Wheat: Leaky Gut

By February 4, 2016Blog

Wheat Gliadin Creates Intestinal Permeability or Leaky Gut

Gliadin, which is a protein in wheat grain, upregulates the production of a protein known as zonulin. Zonulin is a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. It was discovered in 2000 by Alessio Fasano and his team at the University of Maryland School of Medicine.


This means that gliadin increases zonulin in your intestines which then loosens the tight junctions between the one layer of cells that make up the wall of your intestines and allows larger and larger molecules to get through your intestinal wall. These large molecules are not meant to be absorbed and typically are seen by our immune system as foreign and bad. So, our immune system, which is our military against attack from invaders, attacks them. This attack causes increased inflammation in our systems that over time leads to an overactive and exhausted immune system (military) that then starts to think even our native cells are foreign and starts attacking them as well which causes Autoimmune Disease.

Studies have demonstrated a direct connection between the over expression of zonulin and a number of autoimmune disorders: particularly celiac disease and type 1 diabetes.

How to Know if Wheat or Other Foods are Toxic to Your System?

There are all sorts of lab tests to assess a person for food allergies or sensitivities, but they cost a lot of money and for many of my patients the results make it look like they are sensitive to everything. The problem is that so many people have a leaky gut with dysfunctional gaps in the tight junctions between the enterocytes (cells) of the intestinal lining and they are not digesting their foods appropriately enough. As a result, many substances that are trying to be absorbed through the intestinal lining are being seen by the immune system as foreign and initiating an immune/inflammatory response and making us sick.

BUT, there is a way to cleanse and quiet your system on your own and then once it is quiet and not so reactive to systematically expose your system to different foods or food categories and test for yourself whether you are sensitive to wheat or other foods or not. This method is called an Elimination Diet and is the most powerful tool I know of for anyone to use to identify their individual food sensitivities.

I believe in the power of this method so much that I have put together a “Detox Plus Program” that walks anyone through the steps of how to do a 3 week comprehensive elimination detoxifying diet and then how to systematically re-challenge the different foods. My program includes:

  1. A step by step guide to support you through the process
  2. 5 supportive and educational video talks by me educating and empowering you on:
    1. Your body’s detoxification pathways
    2. The Most supportive supplements to take during a detox
    3. Stress reduction methods
    4. How to systematically re-challenge each food or food category correctly to determine your sensitivities.
    5. What to do after your detox is over and where to go from here.

If you would like to learn more about my “Detox Plus Program” then go to my clinical website: www.tmurraywellness.com. From the homepage follow the link to learn how to “Put a DENT in your Pain” through Diet, Exercise, Nutrition and Treatment:

Then, for free:

  1. take the Medical Symptoms Questionaire and score your overall health
  2. Listen to my overview talk on how to Put a DENT in your Pain through Diet, Exercise, Nutrition and Treatment.

Finally, take a look at my “Detox Plus Program” and decide if it may be the answer you are looking for to feel better and empower yourself to optimize your overall health.

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